ACTIVITY OF MIXED ETHANOL EXTRACT SELECTED BLACK TEA (Camelia sinensis L.) AND STEVIA (Stevia rebaudiana B.) AS AN ALTERNATIVE ANTI DIABETES HERBAL MEDICINE

Kusmiyati, Mimin and Trinovani, Elvi and Fauziyah, Roro Nur (2020) ACTIVITY OF MIXED ETHANOL EXTRACT SELECTED BLACK TEA (Camelia sinensis L.) AND STEVIA (Stevia rebaudiana B.) AS AN ALTERNATIVE ANTI DIABETES HERBAL MEDICINE. International Medical Journal, 25 (6). pp. 2469-2478. ISSN 13412051

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Abstract

ABSTRACT— Metabolic syndrome is a syndrome that has the highest risk that can cause death. People who have metabolic syndrome are more prone to Diabetes mellitus (DM) type 2. In an effort to look for alternative low-risk prevention, some plant extracts have been tested for antidiabetic activity, one of which is black tea leaf (Camellia sinensis L.) which is often consumed by people especially in Indonesia. Black tea contains several chemical compounds such as alkaloids, steroids, saponins, flavonoids, tannins, and polyphenols (Sudaryat, 2016). This research was conducted with the aim of finding out the activity of a mixture of ethanol extracts of the selected formula of black tea and stevia as an alternative antidiabetic herbal medicine. The results showed that ethanol extracts of black tea and stevia have antidepressant activity in white mice. Giving ethanol extract of black tea and ethanol extract of stevia in diabetic mice dose I containing ethanol extract of black tea 50 mg/kg BW and stevia 300 mg/kg BW, dose II containing black tea extract 100 mg/kg BW and stevia 200 mg /kg BW and dose III contain 150 mg/kg BW and stevia black tea extract 300 mg/kg BW and dose I had the highest antidiabetic activity compared to other doses with a decrease in blood glucose levels of 69.75 mg/dL.

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